[Remote] Sr. Bioinformatics Scientist (Assay Development Analytics)

Note: The job is a remote job and is open to candidates in USA. Karius is a life science company focused on advancing diagnostic science through microbial insights. The Sr. Bioinformatics Scientist will be a key member of the Assay Development Analytics team, responsible for driving computational aspects of assay development and conducting innovative analyses to enhance diagnostic capabilities for infectious diseases.

Responsibilities

• Individual contributor to Assay Development Analytics (ADA), which drives the computational aspects of assay development, focusing on analysis and optimization of new chemistries and lab techniques.
• Participate in experimental design, conduct computational analyses, understand rationale, set the analysis plan, and execute using the necessary tools and methodologies to deliver innovative assays.
• Work closely with colleagues across the Molecular Biology and Laboratory Operations teams to understand the properties of the assays and ways to improve our technologies.
• Continue to grow and learn in the necessary mathematical, technological, and software aspects of the field through internal knowledge acquisition and staying current with the latest relevant literature.
• Open to exploring multiple approaches for problem-solving and modeling including borrowing across a wide range of quantitative disciplines.
• Ensure high standards of data integrity, quality control, and validation, while maintaining rigorous quality documentation and dissemination of scientific findings.
• Provide clear visibility into areas of ownership and communicate weekly progress and results to stakeholders.
• Continue to grow and learn in the necessary biological/scientific domains and technological aspects of the field through novel knowledge acquisition but also staying current with the latest relevant literature.
• Share a passion for ensuring the quality of our statistical analysis, via reliability, reproducibility, and rigor. Skills
• Ph.D. in computer science, statistics, mathematics, physics, genetics, bioinformatics, metagenomics, or related fields (preferably with a focus on computational biology or machine learning) with 3+ years of postdoctoral and/or industry experience; OR Master’s degree with 5+ years of directly relevant industry experience.
• Publications demonstrating innovative investigation and interpretation of biological data.
• Proven proficiency, and understanding of, modern statistics and machine learning.
• Proven proficiency with high-dimensional, large-scale datasets characterized by low signal-to-noise.
• Demonstrated excellence in communication and collaboration within cross-functional, multidisciplinary teams.
• Self-starter with the ability to independently drive results and influence project direction.
• Evidence of innovation in connecting biological insights to complex mechanisms of microbiome and host–environment interactions.
• Familiarity with a range of relevant laboratory techniques (either through hands-on work or from collaborations with laboratory-focused colleagues).
• Familiarity and experience with bioinformatics tools, approaches, and workflows, particularly those related to next-generation sequencing data analysis.
• Familiarity with design of experiments (DOE) approaches to optimize process settings.
• Passionate, purpose-driven, and excited about Karius’ mission: to conquer infectious diseases through innovations around genomic sequencing and machine learning.
• Excellence at communication and collaboration within a cross-functional team.
• Detail oriented with exceptional organizational and time management skills.
• Self-starting mentality and ability to drive results.
• Comfortable working in an environment which combines both research aspects as well as development.
• Ability to work effectively and efficiently in a fast-paced (startup) environment. Company Overview
• Karius delivers genomic insights into infectious diseases, helping clinicians make critical, life-saving treatment decisions. It was founded in 2014, and is headquartered in Redwood City, California, USA, with a workforce of 51-200 employees. Its website is https://kariusdx.com. Company H1B Sponsorship
• Karius has a track record of offering H1B sponsorships, with 1 in 2024, 4 in 2021. Please note that this does not guarantee sponsorship for this specific role.

Apply tot his job Apply To this Job