Director, Translational PK/PD Data Science

Job title: Director, Translational PK/PD Data Science in San Francisco, CA at MSD Company: MSD Job description: Job DescriptionThe department of Pharmacokinetics, Dynamics, Metabolism & Bioanalytics (PDMB) is seeking a curious and collaborative Scientific Director for our growing Translational PK/PD organization. The Translational PK/PD Director is an expert mathematical modeler and scientist who can lead development of and supervise others in modeling strategy for drug discovery. Directors work with multi-disciplinary discovery teams to enable early, efficient, and successful decisions about PK/PD, modality selection, and dose prediction across all therapeutic areas for small molecule, peptide, and protein therapeutics.The Translational PK/PD Director will serve as an individual contributor and mentor/supervise junior colleagues, with the following responsibilities:Serve as expert representative for PDMB in cross-functional teams, to advance model-informed drug discovery and translational science.Integrate in vitro & in vivo data into systems models (PBPK, PK/PD, mechanistic models) of drug disposition and pharmacology, to support translational and reverse translational efforts across multiple modalities and therapeutic areas;Understand the impact of drug disposition on novel disease biology and pharmacological response (PK/PD) to inform human PK and dose projections;Collaborate across the PDMB organization to develop modeling and simulation strategies to identify and optimize drug candidates;Oversee a group of scientists (in a scientific and/or supervisory role);Mentor / supervise junior colleagues to perform the above duties and to grow the above capabilities.In addition to the responsibilities described above, Directors demonstrate outstanding leadership and communication skills, collaborating across PDMB and with other functional areas to build strategies for quantitative model-informed drug discovery.Note: We are hiring in South San Francisco, CA, Boston, MA or West Point, PA based on candidate preference.Qualifications:Education:

• Master’s (with 11+ years), Ph.D. (with 7+ years) or PharmD (with 9+ years) in a science field and relevant experience listed below

Required Experience and Skills:

• Record of increasing responsibility and independence in a similar role in pharmaceutical drug development or academia setting
• Record of both internal and external impact in driving model-informed drug discovery and translational PK/PD strategies, using modeling software (e.g., Phoenix, Berkeley Madonna, Monolix, Matlab, R)
• Expert skills in experimental design, mathematical problem solving, critical data analysis/interpretation, and statistics

Preferred Experience and Skills:

• Emerging leader in the field of translational PK/PD with a track record of external visibility, through publications, presentations, and/or involvement in professional organizations
• Record of increasing responsibility and leadership in informing drug discovery/development through mathematical modeling
• Demonstrated ability to participate in and to lead interdisciplinary teams, and to scope out, plan, and oversee the work of other scientists
• Expertise in biologics, large molecule, and/or protein therapeutics modeling
• Expertise in PBPK modeling

#EligibleforERPCurrent Employees applyCurrent Contingent Workers applyUS and Puerto Rico Residents Only:Our company is committed to inclusion, ensuring that candidates can engage in a hiring process that exhibits their true capabilities. Please if you need an accommodation during the application or hiring process.As an Equal Employment Opportunity Employer, we provide equal opportunities to all employees and applicants for employment and prohibit discrimination on the basis of race, color, age, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or other applicable legally protected characteristics. As a federal contractor, we comply with all affirmative action requirements for protected veterans and individuals with disabilities. For more information about personal rights under the U.S. Equal Opportunity Employment laws, visit:We are proud to be a company that embraces the value of bringing together, talented, and committed people with diverse experiences, perspectives, skills and backgrounds. The fastest way to breakthrough innovation is when people with diverse ideas, broad experiences, backgrounds, and skills come together in an inclusive environment. We encourage our colleagues to respectfully challenge one another’s thinking and approach problems collectively.U.S. Hybrid Work ModelEffective September 5, 2023, employees in office-based positions in the U.S. will be working a Hybrid work consisting of three total days on-site per week, Monday - Thursday, although the specific days may vary by site or organization, with Friday designated as a remote-working day, unless business critical tasks require an on-site presence.This Hybrid work model does not apply to, and daily in-person attendance is required for, field-based positions; facility-based, manufacturing-based, or research-based positions where the work to be performed is located at a Company site; positions covered by a collective-bargaining agreement (unless the agreement provides for hybrid work); or any other position for which the Company has determined the job requirements cannot be reasonably met working remotely. Please note, this Hybrid work model guidance also does not apply to roles that have been designated as “remote”.The Company is required to provide a reasonable estimate of the salary range for this job in certain states and cities within the United States. Final determinations with respect to salary will take into account a number of factors, which may include, but not be limited to the primary work location and the chosen candidate’s relevant skills, experience, and education.Expected US salary range: $187,000.00 - $294,400.00Available benefits include bonus eligibility, long term incentive if applicable, health care and other insurance benefits (for employee and family), retirement benefits, paid holidays, vacation, and sick days. A summary of benefits is listed .San Francisco Residents Only: We will consider qualified applicants with arrest and conviction records for employment in compliance with the San Francisco Fair Chance OrdinanceLos Angeles Residents Only: We will consider for employment all qualified applicants, including those with criminal histories, in a manner consistent with the requirements of applicable state and local laws, including the City of Los Angeles’ Fair Chance Initiative for Hiring OrdinanceSearch Firm Representatives Please Read Carefully Merck & Co., Inc., Rahway, NJ, USA, also known as Merck Sharp & Dohme LLC, Rahway, NJ, USA, does not accept unsolicited assistance from search firms for employment opportunities. All CVs / resumes submitted by search firms to any employee at our company without a valid written search agreement in place for this position will be deemed the sole property of our company. No fee will be paid in the event a candidate is hired by our company as a result of an agency referral where no pre-existing agreement is in place. Where agency agreements are in place, introductions are position specific. Please, no phone calls or emails.Employee Status: RegularRelocation: Domestic/InternationalVISA Sponsorship: YesTravel Requirements: 10%Flexible Work Arrangements: HybridShift: 1st - DayValid Driving License: NoHazardous Material(s): NoRequired Skills: Business Intelligence (BI), Database Design, Data Engineering, Data Modeling, Data Science, Data Visualization, Machine Learning, Software Development, Stakeholder Relationship Management, Waterfall ModelPreferred Skills:Job Posting End Date: 06/30/2025*A job posting is effective until 11:59:59PM on the day BEFORE the listed job posting end date. Please ensure you apply to a job posting no later than the day BEFORE the job posting end date. Expected salary: Location: San Francisco, CA Apply for the job now! Apply for this job